Contents

For a variety of malignant hematological diseases, hematopoietic stem cell transplantation is the only curative treatment option and the last hope for many leukemia patients. However, more than half of the patients die within the first two years after transplantation because of tumor relapse or graft versus host disease (GVHD). Therefore, there is an urgent medical need for novel treatment strategies in this area. We identified a new approach by therapeutically inhibiting specific genes which are expressed during GVHD-related pathological angiogenesis. In disease-specific mouse models we will test the efficacy of this approach in inhibiting tumor growth by using state-of-the art methods including bioluminescence tumor imaging in an optical small animal imager device and immune status assessment via flow cytometry. The project will be divided in practical lab sessions, data analysis sessions and background seminars, concluding with a final data presentation in an internal symposium.

Contact

katarina.riesner@charite.de

Link to the course catalog

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