Inhalte

Kinases play a crucial role in cell regulation and are potential targets for the development of new drugs against severe diseases such as cancer or cardiovascular diseases. This course aims to investigate kinase inhibitors that utilize specific water networks within the ATP binding pockets. Students will conduct computational molecular dynamics simulations to assess the stability and dynamics of these water networks across the human kinases. Other methods are reporter gene assays to analyze kinase signaling.  The aim is to identify kinases with unique water binding properties that could be exploited for targeted drug development. A second aim is to explain why certain drugs may show specificity for certain kinases. The course is designed for Bachelor’s and Master’s students with a background in natural sciences, particularly in biology, pharmacy, chemistry, bioinformatics, computer science or related fields. Prior knowledge is not mandatory.

Kontakt

leon.obendorf@fu-berlin.de

Link zum Vorlesungsverzeichnis

hier#mce_temp_url#